Related Experiment Video
Updated: Mar 5, 2026
Ultrasonic Assessment of Myocardial Microstructure
Published on: January 14, 2014
Alteration of Time Intervals in Patients With Hypertrophic Cardiomyopathy During an Exercise Echocardiography
Angela Zagatina1, Nadezhda Zhuravskaya1, Tatyana V Tyurina1
1Leningrad Regional Cardiologic Dispensary, St. Petersburg, Russian Federation.
Insights
Hypertrophic cardiomyopathy (HCM) patients exhibit prolonged diastolic relaxation times compared to healthy individuals and those with hypertension. Exercise stress testing reveals significant alterations in these time parameters in HCM patients.
Area of Science:
- Cardiology
- Cardiovascular Physiology
Background:
- Hypertrophic cardiomyopathy (HCM) is frequently linked to diastolic dysfunction.
- Diastolic dysfunction is theoretically more pronounced during physiological stress like exercise.
Purpose of the Study:
- To investigate diastolic function alterations in hypertrophic cardiomyopathy (HCM) patients during exercise.
- To compare diastolic time parameters between HCM patients, essential arterial hypertension (AH) patients, and healthy controls.
Main Methods:
- Eighty-four participants (25 HCM, 25 AH, 34 controls) underwent treadmill echocardiography.
- Measured diastolic parameters included mitral early diastolic filling velocity time (TE) and peak early tissue mitral annular velocity time (Te').
- Assessed isovolumetric relaxation time over TE-Te' ratio (IVRT/(TE-Te')) and their changes during stress.
Main Results:
- HCM patients showed significantly longer resting TE and Te' compared to controls and AH patients.
- Post-exercise, HCM patients exhibited a significantly longer Te' and a higher IVRT/(TE-Te') ratio.
- These findings indicate distinct diastolic time parameter alterations in HCM, even compared to hypertensive individuals.
Conclusions:
- Hypertrophic cardiomyopathy patients demonstrate altered diastolic time parameters.
- These alterations are evident not only compared to healthy individuals but also to patients with essential arterial hypertension.
- Exercise stress echocardiography can unmask significant diastolic dysfunction in HCM.
Background:
Hypertrophic cardiomyopathy (HCM) is often associated with diastolic dysfunction. Theoretically, a more marked alteration of diastolic function is revealed during exercise.
Methods And Results:
We studied 84 persons: 1) 25 patients with HCM, 2) 25 patients with essential arterial hypertension (AH) and 3) 34 healthy controls. Each person performed a treadmill echocardiography. Before and after work, the following parameters were measured: the time interval between the QRS complex and the onset of mitral early diastolic filling velocity (TE), the interval between the QRS complex and the onset of peak early tissue mitral annular velocity (Te'), the isovolumetric relaxation time over the difference of TE and Te' ratio (IVRT/(TE-Te')), and changes of the time parameters during the stress test. In comparison with hypertensive and control groups, HCM patients at rest showed a significantly longer TE (448 ± 55 vs. 423 ± 33 vs. 417 ± 24 ms, P < 0.04) and Te' (446 ± 48 vs. 403 ± 44 vs. 416 ± 38 ms, P < 0.003). After stress the HCM group had a longer Te' (355 ± 59 vs. 299 ± 40 vs. 292 ± 30 ms, P < 0.000004) and a higher IVRT/(TE-Te') ratio (3.1 ± 1.5 vs. 0.9 ± 2.4 vs. 1.7 ± 1.2, P < 0.002).
Conclusions:
HCM patients show an alteration in the time parameters not only compared to healthy persons but to hypertensive patients as well.
More Related Videos
11:50High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
Published on: July 9, 2010
09:05Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
Published on: October 20, 2016
Related Concept Videos
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
01:29Electrocardiogram
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
01:17Imaging Studies for Cardiovascular System I:Echocardiography
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...