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Relationship Between Brachial Artery Flow-Mediated Dilation, Carotid Artery Intima-Media Thickness and Coronary Flow

Fahrettin Oz1, Ali Elitok1, Ahmet Kaya Bilge1

  • 1Department of Cardiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.

Cardiology Research
|March 29, 2017
PubMed

Insights

Coronary flow reserve (CFR) correlates with brachial artery flow-mediated dilation (FMD) and carotid intima-media thickness (IMT) in coronary artery disease (CAD) patients. This suggests CFR may serve as a surrogate marker for coronary atherosclerosis.

Area of Science:

  • Cardiovascular Medicine
  • Diagnostic Imaging
  • Vascular Biology

Background:

  • Coronary artery disease (CAD) assessment relies on various noninvasive markers.
  • Understanding the interrelationships between different vascular health indicators is crucial for risk stratification.

Purpose of the Study:

  • To investigate the relationship between brachial artery flow-mediated dilation (FMD), carotid artery intima-media thickness (IMT), and coronary flow reserve (CFR) in patients with CAD.

Main Methods:

  • Fifty CAD patients and 45 controls underwent high-resolution ultrasound for brachial artery FMD and carotid artery IMT.
  • Transthoracic second harmonic Doppler echocardiography was employed to measure CFR.

Main Results:

  • Significant correlations were observed between CFR, brachial artery FMD, and carotid IMT.
  • CFR showed a positive correlation with brachial artery FMD (r = 0.232, P < 0.05) and a negative correlation with carotid IMT (r = -0.403, P < 0.001).
  • Carotid IMT also correlated negatively with brachial artery FMD (r = -0.211, P < 0.05).

Conclusions:

  • Transthoracic CFR demonstrates correlation with established noninvasive predictors of atherosclerosis.
  • CFR shows potential as a surrogate marker for assessing coronary atherosclerosis.
Abstract

Keywords:
AtherosclerosisCarotid artery intima-media thicknessCoronary artery diseaseCoronary flow reserveEndothelial dysfunctionFlow mediated dilation

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