Related Experiment Video

Updated: Mar 5, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.9K

A phylogenomic framework for assessing the global emergence and evolution of clonal complex 398 methicillin-resistant

Anders Gonçalves da Silva1,2, Sarah L Baines1, Glen P Carter1

  • 11​Doherty Applied Microbial Genomics, Department of Microbiology & Immunology, The University of Melbourne at The Doherty Institute for Infection and Immunity, Melbourne, Australia.

Microbial Genomics
|March 29, 2017
PubMed

Insights

Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) CC398 has spread globally. This study tracked LA-MRSA CC398 incursions into New Zealand, revealing a recent swine-associated clade likely originating from Europe.

Area of Science:

  • Microbiology
  • Genomics
  • Epidemiology

Background:

  • Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is a significant cause of infection in individuals with livestock exposure.
  • Clonal complex 398 (CC398) is the most common LA-MRSA clone globally, found in Europe, the Americas, and Asia.
  • Understanding LA-MRSA CC398 dissemination is crucial for infection control.

Purpose of the Study:

  • To investigate the factors contributing to the global spread of LA-MRSA CC398.
  • To analyze CC398 MRSA isolates from New Zealand (NZ) and global datasets.
  • To understand the origins and spread of LA-MRSA in geographically isolated regions.

Main Methods:

  • Phylogenomic analysis of CC398 MRSA isolates from New Zealand and global datasets.
  • Comparison with methicillin-susceptible Staphylococcus aureus CC398.
  • Bayesian modeling to infer clade emergence and origin.

Main Results:

  • Multiple sporadic introductions of CC398 MRSA into New Zealand were identified.
  • A recent swine-associated clade, linked to European LA-MRSA, was imported and spread within NZ.
  • Bayesian modeling indicated this NZ clade emerged in the late 2000s, likely from European swine.

Conclusions:

  • The study elucidates the pathways of LA-MRSA CC398 incursion and spread into geographically isolated regions like New Zealand.
  • Findings provide insights into global Staphylococcus aureus transmission dynamics.
  • This research will inform strategies for controlling the importation and spread of LA-MRSA.
Keywords:
Livestock-MRSAStaphylococcus aureusepidemiologyswinezoonosis

More Related Videos

Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus09:03

Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus

Published on: September 5, 2013

12.4K
Genotyping of Staphylococcus aureus by Ribosomal Spacer PCR RS-PCR08:51

Genotyping of Staphylococcus aureus by Ribosomal Spacer PCR RS-PCR

Published on: November 4, 2016

10.2K

Related Concept Videos

Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
786
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.1K
Applications of Molecular Taxonomy01:20

Applications of Molecular Taxonomy

Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...
638
Microbial Classification System01:24

Microbial Classification System

Classification is the process of organizing organisms into hierarchically inclusive groups based on their phenotypic similarities or evolutionary relationships. A species comprises one or more strains, and closely related species are grouped into genera. Genera are further classified into families, families into orders, orders into classes, and so forth, up to the domain level, which is the broadest taxonomic rank derived from a combination of phenotypic and genotypic data.The nomenclature of...
1.5K
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
3.2K