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Increased Body Temperature01:25

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A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
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Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
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A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
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Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
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Central Hyperthermia Treated with Bromocriptine.

P Natteru1, P George2, R Bell3

  • 1Department of Neurology, University of Missouri, 5 Hospital Drive, CE 540, Columbia, MO 65211, USA.

Case Reports in Neurological Medicine
|March 29, 2017
PubMed
Summary
This summary is machine-generated.

Central hyperthermia in brain injury patients is common and difficult to treat. Bromocriptine effectively controlled intractable fevers in a patient with thalamic hemorrhage, suggesting its therapeutic potential.

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Area of Science:

  • Neurology
  • Critical Care Medicine

Background:

  • Central hyperthermia is a frequent complication in patients with brain injury.
  • It presents with rapid onset, high temperatures, and poor response to conventional treatments.
  • Associated with worse patient outcomes, necessitating aggressive management.

Observation:

  • A 34-year-old male with thalamic hemorrhage developed intractable fevers up to 39.3°C.
  • Standard treatments including antibiotics, antipyretics, and cooling wraps were ineffective.
  • Infectious workup yielded unremarkable results.

Findings:

  • Bromocriptine administration resulted in effective control of central hyperthermia.
  • Fever spikes were reduced to minor fluctuations, worsening upon attempted weaning.
  • This indicates bromocriptine's significant role in managing drug-resistant fevers.

Implications:

  • Highlights the diagnostic and therapeutic challenges of central hyperthermia.
  • Suggests bromocriptine as a potentially beneficial treatment option.
  • Emphasizes the need for exploring novel therapeutic strategies for brain injury-related hyperthermia.