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Aerobic Training Intensity for Improved Endothelial Function in Heart Failure Patients: A Systematic Review and
1School of Science and Technology, University of New England, Armidale, NSW 2351, Australia.
Cardiology Research and Practice
|March 29, 2017
Summary
Aerobic exercise training, both vigorous and moderate, significantly improves flow-mediated dilation (FMD) in heart failure patients. This meta-analysis quantifies the positive impact of exercise intensity on endothelial function.
Area of Science:
- Cardiovascular Research
- Exercise Physiology
- Clinical Trials
Background:
- Endothelial dysfunction is a hallmark of heart failure.
- Flow-mediated dilation (FMD) is a key indicator of endothelial function.
- Existing literature suggests aerobic exercise benefits FMD in heart failure.
Purpose of the Study:
- To meta-analyze the impact of aerobic training intensity on FMD in heart failure patients.
- To quantify the relationship between exercise intensity and endothelial function improvements.
Main Methods:
- Systematic literature search of PubMed, Embase, ProQuest, and Cochrane Trials Register up to June 2016.
- Inclusion of exercise-based rehabilitation trials in heart failure patients.
- Analysis of studies examining exercise training, endothelial function, and FMD.
Main Results:
- 13 studies with 458 participants (264 intervention, 194 control) were included.
- Both vigorous and moderate intensity aerobic training demonstrated significant improvements in FMD.
- Aerobic exercise positively impacts endothelial function in heart failure.
Conclusions:
- Both vigorous and moderate aerobic exercise training are effective in improving FMD in heart failure.
- Exercise interventions can enhance endothelial function in this patient population.
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