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Immediate access to antiretroviral therapy is important in children living with HIV

Sangeeta Das Bhattacharya1, Bikas K Arya1

  • 1School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, India.

Journal of Family Medicine and Primary Care
|March 29, 2017
PubMed

Insights

Delayed antiretroviral therapy (ART) in children with perinatal HIV significantly hinders immunization response and growth. Early ART access is crucial for HIV-infected Indian children, irrespective of CD4 count, aligning with global treatment guidelines.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Immunology

Background:

  • Pneumonia prevention in HIV-infected children is a critical public health concern.
  • Antiretroviral therapy (ART) is central to managing pediatric Human Immunodeficiency Virus (HIV).
  • Global guidelines for initiating ART in children are evolving, necessitating timely updates.

Observation:

  • A case report details a child with perinatal HIV followed for 30 months.
  • The study focused on a prospective cohort investigating pneumonia prevention strategies.
  • This case highlights the impact of delayed ART initiation on child health outcomes.

Findings:

  • Delayed access to antiretroviral therapy (ART) negatively affects immunization response in HIV-infected children.
  • Impaired growth was observed in children with delayed ART initiation.
  • The findings underscore the importance of timely ART for pediatric HIV management.

Implications:

  • This case emphasizes the urgent need for accessible ART for all HIV-infected Indian children, regardless of CD4 T-cell count.
  • The findings support the World Health Organization's (WHO) revised guidelines on early ART initiation.
  • Timely ART access is essential for improving long-term health, growth, and immune reconstitution in vertically HIV-infected children.

Keywords:
AccessHIVantiretroviral therapyimmune responsevaccines

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