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Related Experiment Video

Updated: Mar 5, 2026

Osteoarthritis Pain Model Induced by Intra-Articular Injection of Mono-Iodoacetate in Rats

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Published on: May 20, 2020

Arthritis models: usefulness and interpretation.

Natacha Bessis¹, Patrice Decker¹, Eric Assier¹

¹INSERM UMR 1125 Sorbonne Paris Cité, Université Paris 13, 74 rue Marcel Cachin, 93000, Bobigny, France.

Seminars in Immunopathology

|March 29, 2017

Summary

This summary is machine-generated.

Animal models are crucial for understanding rheumatoid arthritis (RA) mechanisms and developing therapies. These models have guided research into immunity, T and B cells, and led to treatments like anti-TNF therapy.

Keywords:

Arthritis models Collagen-induced arthritis Inflammation Rheumatoid arthritis

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Area of Science:

Rheumatology
Immunology
Translational Medicine

Background:

Animal models are essential for elucidating arthritis pathophysiology and identifying therapeutic targets.
Rheumatoid arthritis (RA) research heavily relies on various animal models to study disease mechanisms.

Purpose of the Study:

To review the utility of current animal models in understanding RA mechanisms.
To highlight the role of these models in the development of targeted therapies.

Main Methods:

Focus on commonly used RA models, including collagen-induced arthritis and KBN mice.
Discussion of spontaneous arthritis models like human TNF-α transgenic mice.

Main Results:

Animal models have been invaluable in understanding innate immunity, T/B cell roles, vascular involvement, and microbiota in RA.
Models facilitated the in vivo application of cytokine-blocking strategies (anti-TNF, anti-IL-6).

Conclusions:

Animal models are indispensable for RA research, driving mechanistic insights and therapeutic innovations.
Emphasizes the ethical use of animal models and high-level experimental design for novel discoveries.
Integrated research, including translational studies, is key for interpreting data from animal models.