Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

285
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
285
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

558
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
558
Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

1.7K
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
1.7K
Antihypertensive Drugs: Action of Diuretics01:16

Antihypertensive Drugs: Action of Diuretics

2.6K
Diuretics are antihypertensive drugs used to treat hypertension resulting from sodium and water retention. Sodium, vital for fluid balance and nerve or muscle function, is regulated by the kidneys through millions of nephrons. Blood enters nephrons via afferent arterioles, which branch into capillaries called glomeruli. These filter blood plasma, allowing water and solutes, like sodium ions, to pass through capillary walls into Bowman's capsule. The filtrate then flows through various...
2.6K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

787
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
787
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

402
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
402

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to the Letter to the Editor-Comment on 'The Effect of Theory-Guided Positive Psychological Interventions for Patients With Breast Cancer: A Systematic Review and Meta-Analysis'.

Journal of clinical nursing·2026
Same author

From trial-and-error to intelligent prediction: Machine learning drives eco-efficient gold leaching in e-waste.

Journal of environmental management·2026
Same author

Effect of on-demand immunosuppressive therapy on long-term outcomes in patients with immunoglobulin A nephropathy: A real-world cohort study.

Nephrologie & therapeutique·2026
Same author

Effects of pulmonary rehabilitation in people with lung cancer after lung resection: a systematic review and meta-analysis.

Journal of cancer survivorship : research and practice·2026
Same author

Machine learning for efficient prediction and optimization of platinum group metal recovery from spent automotive catalysts.

Waste management (New York, N.Y.)·2025
Same author

The Effect of Theory-Guided Positive Psychological Interventions for Patients With Breast Cancer: A Systematic Review and Meta-Analysis.

Journal of clinical nursing·2025

Related Experiment Video

Updated: Mar 5, 2026

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
07:38

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

8.9K

Hydroxychloroquine alleviates persistent proteinuria in IgA nephropathy.

Ruitong Gao1, Wei Wu2, Yubing Wen1

  • 1Division of Nephrology, Department of Internal Medicine, Peking Union Medical College Hospital, Beijing, 100730, People's Republic of China.

International Urology and Nephrology
|March 29, 2017
PubMed
Summary

Hydroxychloroquine (HCQ) effectively reduced proteinuria in IgA nephropathy (IgAN) patients. This study found HCQ significantly improved proteinuria levels compared to losartan alone in IgAN patients.

Keywords:
HydroxychloroquineIgA nephropathyProteinuriaRemission

More Related Videos

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy
14:18

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Published on: October 13, 2023

1.8K
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.6K

Related Experiment Videos

Last Updated: Mar 5, 2026

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
07:38

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

8.9K
Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy
14:18

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Published on: October 13, 2023

1.8K
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.6K

Area of Science:

  • Immunology
  • Nephrology
  • Pharmacology

Background:

  • Dendritic cells, Toll-like receptors (TLRs), and cytokines like IFN-α, IL-6, and TNF-α are implicated in IgA nephropathy (IgAN) pathogenesis.
  • Hydroxychloroquine (HCQ), an antimalarial drug, modulates immune responses by reducing activated immune cells and cytokine production.
  • HCQ's immunomodulatory effects suggest potential therapeutic benefits in autoimmune and inflammatory kidney diseases.

Purpose of the Study:

  • To evaluate the efficacy of Hydroxychloroquine (HCQ) in reducing proteinuria in patients diagnosed with IgA nephropathy (IgAN).
  • To assess if HCQ, in addition to losartan, offers superior proteinuria reduction compared to losartan monotherapy in IgAN patients.

Main Methods:

  • A prospective, paired case-control study involving 28 IgAN patients with persistent proteinuria despite 3 months of losartan treatment.
  • Patients were assigned to either HCQ plus losartan (group 1) or continued losartan therapy alone (group 2) for 24 weeks.
  • The primary endpoint was a reduction in proteinuria by 50% or more from baseline levels.

Main Results:

  • Significantly more patients in the HCQ group (42.9%) achieved the primary endpoint compared to the control group (14.3%) (P=0.004).
  • By week 24, mean urinary protein excretion decreased to 65.9% of baseline in the HCQ group (P=0.002), versus 95.3% in the control group (P=0.791).
  • No significant differences were observed in baseline proteinuria, histologic grades, blood pressure, serum creatinine, or eGFR changes between groups.

Conclusions:

  • Hydroxychloroquine (HCQ) demonstrates efficacy in ameliorating proteinuria in selected IgA nephropathy (IgAN) patients.
  • HCQ may be a valuable therapeutic option for managing proteinuria in IgAN when added to standard treatment like losartan.