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Related Concept Videos

Cell Migration01:09

Cell Migration

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Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
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Cell Migration01:19

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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Migration00:53

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Migration is long-range, seasonal movement from one region or habitat to another. This common strategy, carried out by many different organisms around the world, is an adaptive response that typically corresponds to changes in an organism’s environment, like resource availability or climate. Migrations can involve huge groups of thousands of animals as well as single individuals traveling alone and can range from thousands of kilometers to just a few hundred meters.
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Cytoskeletal Coordination in Cell Migration01:32

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A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
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Chemotaxis and Direction of Cell Migration01:21

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Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
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Homeostatic Imbalance01:10

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Homeostasis is the maintenance of a stable internal environment within the body, which is crucial for the proper functioning of cells, tissues, organs, and organ systems. The body has various control mechanisms that work together to regulate various physiological parameters such as temperature, blood pressure, pH balance, and fluid balance, to name a few. These control mechanisms are based on feedback loops that can be either positive or negative.
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Study of Cell Migration in Microfabricated Channels
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Introduction to Homeostatic Migration.

Mark C Coles1

  • 1Department of Biology, Centre for Immunology and Infection, University of York, York, North Yorkshire, YO10 5DD, UK. mark.coles@york.ac.uk.

Methods in Molecular Biology (Clifton, N.J.)
|March 29, 2017
PubMed
Summary
This summary is machine-generated.

Immune cell development relies on migration within specialized tissues. Advanced imaging and computational methods reveal how stromal cells support immune cell function and survival.

Keywords:
3D imagingMigrationModelingMultiphotonThymus

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Area of Science:

  • Immunology
  • Cell Biology
  • Biophysics

Background:

  • Immune cell development and function depend on specialized immunological tissues.
  • Hematopoietic cells interact with stromal cells for migration, antigen presentation, and survival signals.

Purpose of the Study:

  • To explore cell migration and function within immunological tissues.
  • To understand the role of stromal cells in supporting immune cell activities.

Main Methods:

  • Utilizing advanced imaging technologies like multiphoton microscopy.
  • Employing 3D tissue reconstruction techniques.
  • Integrating computational approaches with experimental data.

Main Results:

  • New insights into the dynamics of cell migration in immune tissues.
  • Detailed understanding of hematopoietic-stromal cell interactions.
  • Elucidation of microenvironmental contributions to immune cell survival and function.

Conclusions:

  • Technical advancements are crucial for studying immune cell dynamics.
  • Stromal cell networks play a vital role in immune cell regulation.
  • Combined imaging and computational methods offer powerful tools for immunological research.