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Comparing stochastic proton interactions simulated using TOPAS-nBio to experimental data from fluorescent nuclear

T S A Underwood1,2, W Sung1,3, C H McFadden4

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|March 29, 2017
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Summary
This summary is machine-generated.

This study validates Monte Carlo (MC) simulations of proton interactions using fluorescent nuclear track detectors (FNTDs). The findings show a strong correlation between simulated proton energy deposition and experimental detector brightness, paving the way for sub-cellular scale MC validation.

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Area of Science:

  • Medical Physics
  • Radiation Biology
  • Computational Science

Background:

  • Monte Carlo (MC) simulations are crucial for modeling proton energy deposition in radiotherapy.
  • Microscopic validation of MC simulations and experimental metrology for individual proton tracks are currently lacking.
  • Fluorescent nuclear track detectors (FNTDs) offer potential for studying individual proton tracks.

Purpose of the Study:

  • To compare microscopic proton interaction simulations with experimental data from FNTDs.
  • To validate the TOPAS-nBio MC platform at the sub-cellular level.
  • To explore the potential of FNTDs for experimental microdosimetry of proton tracks.

Main Methods:

  • Proton irradiation of Al2O3:C,Mg FNTDs within a water phantom at various depths along a Bragg peak.
  • MC simulations using TOPAS and TOPAS-nBio with Geant4-DNA physics to model proton interactions.
  • Analysis of FNTD track integrated brightness (IB) and comparison with simulated linear energy transfer (LET) and lineal energy (y).

Main Results:

  • A strong correlation was observed between measured FNTD track IB and simulated voxelized track-averaged LET and microdosimetric lineal energy (y).
  • Histograms of FNTD track IB closely matched TOPAS-nBio simulations of terminal electrons per proton.
  • Experimental trends in FNTD track IB replicated those seen in MC simulations across different exposure depths.

Conclusions:

  • This study provides the first experimental validation of MC simulations at the sub-cellular scale using FNTDs.
  • FNTDs show promise for enabling experimental studies of individual proton track microdosimetric properties.
  • The results support the use of TOPAS-nBio for accurate simulation of proton interactions relevant to radiobiology.