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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
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MicroRNAs Make a Difference in Cardiovascular Robustness.

Rachael Bakker1, Richard W Carthew2

  • 1Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.

Developmental Cell
|March 29, 2017
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Summary
This summary is machine-generated.

MicroRNAs (miRNAs) in invertebrates reduce developmental variations from environmental and genetic factors. Zebrafish miRNAs similarly minimize cardiovascular development variability in embryos, highlighting a conserved role for miRNAs in biological robustness.

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Area of Science:

  • Developmental biology
  • Genetics
  • Molecular biology

Background:

  • MicroRNAs (miRNAs) are known regulators of gene expression.
  • Invertebrate miRNAs have been shown to buffer developmental variability.
  • Environmental and genetic factors can introduce variability during development.

Purpose of the Study:

  • To investigate the role of miRNAs in cardiovascular development in zebrafish.
  • To determine if miRNAs suppress developmental variability in vertebrates.
  • To understand the conserved mechanisms linking miRNAs and developmental robustness.

Main Methods:

  • Utilized zebrafish (Danio rerio) as a model organism.
  • Employed genetic and molecular techniques to study miRNA function.
  • Analyzed cardiovascular development during embryogenesis.

Main Results:

  • Zebrafish miRNAs were found to suppress variability in cardiovascular development.
  • This suppression occurs during the embryonic stage.
  • The findings suggest a conserved role for miRNAs in ensuring developmental stability.

Conclusions:

  • MicroRNAs play a crucial role in maintaining cardiovascular developmental robustness in zebrafish.
  • The findings extend the known functions of miRNAs from invertebrates to vertebrates.
  • This study provides insight into the conserved link between miRNAs and developmental stability across species.