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Ladan Mehran1, Atieh Amouzegar1, Parnian Kheirkhah Rahimabad1
1Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, I. R. Iran.
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|March 29, 2017
Summary
Thyroid dysfunction, particularly overt hypothyroidism, is linked to metabolic syndrome (MetS) and its components like abdominal obesity and high triglycerides. Subclinical hypothyroidism in older adults and hyperthyroidism may also increase risks.
Area of Science:
- Endocrinology
- Metabolic Health
- Public Health
Background:
- The relationship between subclinical thyroid dysfunction and metabolic syndrome (MetS) remains unclear.
- Thyroid hormones play a crucial role in regulating metabolism.
Purpose of the Study:
- To investigate the association between thyroid dysfunction, including subclinical ranges, and the prevalence of MetS and its components.
- To identify specific thyroid function statuses associated with increased MetS risk.
Main Methods:
- A cross-sectional study of 5,422 adults from the Tehran Thyroid Study, excluding individuals with thyroid disease, pregnancy, or severe systemic conditions.
- Measurements included anthropometrics (weight, waist circumference), blood pressure, fasting glucose, lipid profiles, free T4, and TSH.
- Statistical analysis examined the odds ratios for MetS and its components across different thyroid function categories.
Main Results:
- MetS was prevalent in 32% of participants. Overt hypothyroidism showed the highest prevalence of MetS (41.6%), abdominal obesity (45%), and hypertriglyceridemia (58%).
- Overt hypothyroidism was significantly associated with MetS in men (OR: 2.9). Subclinical hypothyroidism posed a higher risk in subjects over 50.
- Hyperthyroidism (overt and subclinical) was linked to a higher likelihood of hyperglycemia in both genders.
Conclusions:
- Overt hypothyroidism is associated with metabolic syndrome, particularly in men.
- Subclinical hypothyroidism, especially in the elderly, may also contribute to MetS.
- Hyperthyroidism appears to be a risk factor for hyperglycemia.