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Updated: Mar 5, 2026
06:53
Quantification of γH2AX Foci in Response to Ionising Radiation
Published on: April 6, 2010
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gamma-H2AX: Can it be established as a classical cancer prognostic factor?
Viktoria-Varvara Palla1, Georgios Karaolanis2, Ioannis Katafigiotis3
11 Department of Obstetrics and Gynecology, Diakonie-Klinikum Schwäbisch Hall, Schwäbisch Hall, Germany.
Summary
Gamma-H2AX, a marker of DNA double-strand breaks, shows potential as a cancer biomarker. Further research is needed to confirm its prognostic value across various cancer types.
Area of Science:
- Molecular Biology
- Oncology
- Biochemistry
Background:
- Double-strand breaks are critical in cancer development.
- Gamma-H2AX forms at DNA breaks, indicating genomic instability.
- Gamma-H2AX is explored as a potential biomarker in various cancers.
Purpose of the Study:
- To review the role of gamma-H2AX in the cell cycle and DNA damage response.
- To investigate gamma-H2AX formation in different cancer types.
- To assess the prognostic value of gamma-H2AX in cancer.
Main Methods:
- Literature review on gamma-H2AX formation and function.
- Analysis of studies investigating gamma-H2AX in various cancers.
- Correlation analysis of gamma-H2AX with other prognostic factors.
Main Results:
- Gamma-H2AX formation is a response to DNA double-strand breaks.
- Gamma-H2AX has been detected in breast, lung, colon, cervix, and ovary cancers.
- Prognostic value is suggested in breast and endometrial cancers, but requires more data.
Conclusions:
- Gamma-H2AX is a sensitive marker of DNA damage and genomic instability.
- Its potential as a pan-cancer biomarker warrants further investigation.
- Establishing gamma-H2AX as a classical prognostic factor requires more extensive research.
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