Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genetic Screens02:46

Genetic Screens

5.8K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.8K
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

55
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
55
Incomplete Dominance01:43

Incomplete Dominance

31.4K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
31.4K
Obesity01:24

Obesity

1.5K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.5K
Human Genetics01:28

Human Genetics

1.8K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.8K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

38.1K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
38.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polygenic risk scores in routine genetic diagnostics: what lies ahead?

Journal of community genetics·2025
Same author

Development of the Dutch translational knowledge agenda for inherited metabolic diseases.

JIMD reports·2024
Same author

Obesity and Hyperphagia With Increased Defective ACTH: A Novel POMC Variant.

The Journal of clinical endocrinology and metabolism·2022
Same author

Fraser syndrome without cryptophthalmos: Two cases.

European journal of medical genetics·2020
Same author

Genetic Obesity and Bariatric Surgery Outcome in 1014 Patients with Morbid Obesity.

Obesity surgery·2019
Same author

Thyroid-stimulating hormone levels in the normal range and incident type 2 diabetes mellitus.

Acta diabetologica·2018

Related Experiment Video

Updated: Mar 5, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

5.3K

[Genetic obesity: new diagnostic options].

T I de Vries1, S I M Alsters, L Kleinendorst

  • 1UMC Utrecht, afd. Medische Genetica, Utrecht.

Nederlands Tijdschrift Voor Geneeskunde
|March 30, 2017
PubMed
Summary

Genetic analysis of 50 obesity-associated genes aids in understanding the multifactorial causes of obesity. Identifying genetic defects can personalize treatment strategies for morbid obesity, improving patient outcomes.

More Related Videos

In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

21.4K
Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

Published on: August 21, 2016

13.6K

Related Experiment Videos

Last Updated: Mar 5, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

5.3K
In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

21.4K
Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

Published on: August 21, 2016

13.6K

Area of Science:

  • Genetics
  • Endocrinology
  • Public Health

Background:

  • Obesity is a significant global health concern, increasing morbidity and mortality.
  • Obesity results from complex interactions between environmental and genetic factors.
  • Monogenic causes, like MC4R gene mutations, account for about 5% of morbid obesity cases.

Purpose of the Study:

  • To investigate the genetic underpinnings of obesity.
  • To offer diagnostic analysis of 50 obesity-associated genes for morbidly obese patients.
  • To explore how genetic defects influence treatment response.

Main Methods:

  • Diagnostic genetic analysis of 50 obesity-associated genes.
  • Clinical evaluation of morbidly obese patients.
  • Correlation of genetic findings with treatment outcomes.

Main Results:

  • Identification of specific genetic defects in morbidly obese individuals.
  • Demonstration that genetic variations can impact treatment efficacy.
  • VU University Medical Center provides genetic testing for obesity.

Conclusions:

  • Understanding obesity genetics is crucial for developing personalized treatments.
  • Genetic insights enable tailored therapeutic approaches for morbid obesity.
  • Genetic analysis can optimize treatment selection for obese patients.