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Clonal analysis as a prognostic factor in multiple oral squamous cell carcinoma.
D B Gissi1, A Tarsitano2, E Leonardi3
1Department of Biomedical and Neuromotor Sciences, Section of Oral Sciences, University of Bologna, Italy.
Oral Oncology
|March 30, 2017
Summary
Mitochondrial DNA (mtDNA) analysis helps classify secondary oral squamous cell carcinoma (OSCC) into local recurrence (LR), second primary tumor (SPT), or second field tumor (SFT). Identifying SFTs, derived from an altered mucosal field, is linked to significantly better survival rates.
Area of Science:
- Oncology
- Genetics
Background:
- Oral squamous cell carcinoma (OSCC) can manifest as secondary tumors, requiring accurate classification for prognostic assessment.
- Distinguishing between local recurrence (LR), second primary tumor (SPT), and second field tumor (SFT) is crucial for understanding tumor origin and patient outcomes.
Purpose of the Study:
- To apply mitochondrial DNA (mtDNA) analysis to differentiate secondary OSCCs into LR, SPT, and SFT categories.
- To evaluate the prognostic impact of these classifications on patient survival rates.
Main Methods:
- Mitochondrial DNA (mtDNA) D-loop analysis was performed on paired neoplastic lesions and normal mucosa from 23 patients with secondary OSCC.
- Secondary tumors were classified as LR, SPT, or SFT based on mtDNA results.
- Disease-free survival was calculated from the appearance of the second lesion to disease-related death or last follow-up.
Main Results:
- Seven secondary tumors were classified as LR, 12 as SFT, and 4 as SPT.
- Patients with SFTs (derived from an altered mucosal field) demonstrated significantly better survival rates (16.6% failure) compared to LRs (71.4% failure) and SPTs (75% failure).
Conclusions:
- Mitochondrial DNA (mtDNA) analysis is a valuable tool for classifying secondary OSCCs.
- Accurate classification of secondary OSCCs can inform treatment decisions and improve patient prognosis.
