Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Other Glycolytic Pathways01:24

Other Glycolytic Pathways

660
The pentose phosphate pathway (PPP) operates in parallel with glycolysis, facilitating the metabolism of both pentoses and glucose. This pathway consists of two distinct phases: the oxidative and non-oxidative phases. While it does not directly generate ATP, the intermediates formed during the process can integrate into glycolysis, contributing to cellular energy metabolism when required.Oxidative Phase: NADPH ProductionThe oxidative phase of the pentose phosphate pathway is primarily...
660
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

624
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
624
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

18.2K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
18.2K
Regulation of Metabolism01:19

Regulation of Metabolism

11.2K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
11.2K
Protein Import into the Peroxisomes01:27

Protein Import into the Peroxisomes

5.0K
Cells contain membrane-bound organelles called peroxisomes that oxidize organic molecules by transferring hydrogen atoms to oxygen, producing hydrogen peroxide. Peroxisomes enzymatically convert the released hydrogen peroxide into water and oxygen.
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
5.0K
Translocation of Proteins into the Mitochondria01:19

Translocation of Proteins into the Mitochondria

11.6K
Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
11.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Core Symptoms and Candidate Targets for Symptom Management in Late Pregnancy: A Network Analysis.

Journal of multidisciplinary healthcare·2026
Same author

miR-885-3p promotes hepatocellular carcinoma metastasis by targeting TASP1 to stabilize HIF-1α and activate hypoxia-driven angiogenic and invasive programs.

Molecular biology reports·2026
Same author

SlMED25-SlPHR3-SlSPX2 module fine-tunes SlPHR3-mediated transcriptional activation of phosphate starvation response in tomato.

Journal of integrative plant biology·2026
Same author

Genome-wide identification and alkaline stress response analysis of the class III peroxidase (PRX) gene family in Castanea mollissima.

BMC plant biology·2026
Same author

Cooking mode shapes Yuxiang shredded pork flavor signatures: a comparative multi-omics study.

Food chemistry·2026
Same author

Extracellular matrix-growth factor signalling drives the oncogenic mir-125b-2/UCK2 axis in hepatocellular carcinoma.

Hereditas·2026

Related Experiment Video

Updated: Dec 19, 2025

Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess
07:35

Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess

Published on: June 1, 2022

2.5K

Uncoupling protein 2 and metabolic diseases.

Annapoorna Sreedhar1, Yunfeng Zhao1

  • 1Department of Pharmacology, Toxicology & Neuroscience, LSU Health Sciences Center in Shreveport, Shreveport, LA 71130, USA.

Mitochondrion
|March 30, 2017
PubMed
Summary

Mitochondria are vital for cell metabolism and development. This review focuses on uncoupling protein 2

Area of Science:

  • Cellular Biology
  • Mitochondrial Biology
  • Metabolic Diseases

Background:

  • Mitochondria are crucial for cellular metabolism and mammalian development.
  • Mitochondrial dysfunction is linked to neurodegenerative and metabolic disorders.
  • Uncoupling protein 2 (UCP2) is implicated in mitochondrial-associated metabolic diseases.

Purpose of the Study:

  • To summarize recent advancements in uncoupling protein 2 research.
  • To explore the role of UCP2 in mitochondrial-associated metabolic diseases.

Main Methods:

  • Literature review of recent developments in UCP2 research.
  • Analysis of UCP2's involvement in mitochondrial function and metabolic disease.

Main Results:

Keywords:
CancerDiabetesMetabolic disorderMitochondrial dysfunctionObesityUncoupling proteins

More Related Videos

Exploring Mitochondrial Energy Metabolism of Single 3D Microtissue Spheroids Using Extracellular Flux Analysis
08:15

Exploring Mitochondrial Energy Metabolism of Single 3D Microtissue Spheroids Using Extracellular Flux Analysis

Published on: February 3, 2022

3.5K
Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

12.1K

Related Experiment Videos

Last Updated: Dec 19, 2025

Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess
07:35

Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess

Published on: June 1, 2022

2.5K
Exploring Mitochondrial Energy Metabolism of Single 3D Microtissue Spheroids Using Extracellular Flux Analysis
08:15

Exploring Mitochondrial Energy Metabolism of Single 3D Microtissue Spheroids Using Extracellular Flux Analysis

Published on: February 3, 2022

3.5K
Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

12.1K
  • Uncoupling proteins, including UCP2, are key regulators of mitochondrial function.
  • UCP2 plays a significant role in oxidative stress and energy metabolism.
  • Recent studies highlight UCP2's complex involvement in various metabolic diseases.

Conclusions:

  • Uncoupling protein 2 is a critical factor in mitochondrial-associated metabolic diseases.
  • Further research into UCP2 mechanisms is essential for understanding and treating metabolic disorders.
  • UCP2 represents a potential therapeutic target for metabolic diseases.