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Association between Helicobacter pylori infection and angiographically demonstrated coronary artery disease: A

Xin-Juan Yu1, Xuan Yang2, Lei Feng3

  • 1Central Laboratories, Qingdao Municipal Hospital, Qingdao, Shandong 266000, P.R. China.

Experimental and Therapeutic Medicine
|March 30, 2017
PubMed

Insights

Helicobacter pylori infection may increase the risk of coronary artery disease (CAD). This meta-analysis found a significant association, particularly in younger individuals and certain ethnicities.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Coronary artery disease (CAD) is a major global cause of mortality.
  • The precise etiology and pathogenesis of CAD remain incompletely understood.
  • Investigating potential infectious links to CAD is crucial for understanding disease development.

Purpose of the Study:

  • To conduct a meta-analysis estimating the association between Helicobacter pylori (H. pylori) infection and the risk of CAD.
  • To evaluate the strength of this association using pooled data from eligible studies.
  • To explore potential moderating factors such as age and geographical region.

Main Methods:

  • A comprehensive literature search was performed for studies published before August 14, 2014.
  • Meta-analytical methods (fixed or random effects) were employed to pool data from 26 cross-sectional studies.
  • Odds ratios (OR) with 95% confidence intervals (CI) were calculated to quantify the association.

Main Results:

  • Helicobacter pylori infection was significantly associated with an increased risk of CAD (OR: 1.96, 95% CI: 1.47-2.63).
  • After adjusting for confounding factors, the association remained significant (OR: 1.42, 95% CI: 1.09-1.86).
  • The association was stronger in younger individuals and observed in studies from Europe and the USA.

Conclusions:

  • A potential association exists between H. pylori infection and an elevated risk of CAD.
  • Age and ethnicity may influence the strength of the H. pylori-CAD association.
  • Further research is warranted to elucidate the causal mechanisms linking H. pylori to cardiovascular disease.

Keywords:
Helicobacter pyloricoronary artery diseasemeta-analysissubgroup analysis

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