Related Experiment Video

Updated: Mar 5, 2026

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
11:50

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

Published on: July 9, 2010

24.8K

Systolic Strain Abnormalities to Predict Hospital Readmission in Patients With Heart Failure and Normal Ejection

Steven M Borer1, Aravind Kokkirala1, David M O'Sullivan1

  • 1Henry Low Heart Center, Hartford Hospital, Hartford, CT, USA.

Cardiology Research
|March 30, 2017
PubMed

Insights

Subtle systolic abnormalities in heart failure with normal ejection fraction (HFNEF) do not predict readmission. However, elevated E/e' measurements are a significant predictor of hospital readmission in HFNEF patients.

Area of Science:

  • Cardiology
  • Echocardiography
  • Heart Failure Research

Background:

  • The pathogenesis of heart failure with normal ejection fraction (HFNEF) remains incompletely understood.
  • Subtle systolic function abnormalities are hypothesized to contribute to HFNEF.
  • Investigating systolic strain and strain rate as potential markers for adverse outcomes in HFNEF.

Purpose of the Study:

  • To evaluate the role of systolic strain and strain rate in predicting hospital readmission for HFNEF.
  • To identify echocardiographic markers associated with adverse outcomes in HFNEF patients.

Main Methods:

  • Analysis of 100 consecutive patients with new-onset HFNEF (left ventricular ejection fraction > 50%).
  • Exclusion of patients with myocardial infarction, severe valvular disease, or severe left ventricular hypertrophy.
  • Measurement of average peak systolic strain and strain rate using off-line grey scale imaging.
  • Comparison of systolic parameters and E/e' between readmitted and readmission-free patient groups.

Main Results:

  • Systolic strain and strain rates were reduced in HFNEF patients compared to controls, but did not differ significantly between readmitted and readmission-free groups.
  • Readmitted patients showed significantly higher E/e' ratios compared to those free from readmission (14.5 vs. 11.0, P=0.013).
  • Elevated E/e' was identified as an independent predictor of HFNEF readmission (OR 1.189, P=0.021).

Conclusions:

  • Reduced systolic strain and strain rates in HFNEF patients do not predict hospital readmission.
  • Elevated E/e' is a significant independent predictor of readmission in patients with HFNEF.
  • E/e' may serve as a valuable prognostic marker for HFNEF management and risk stratification.
Abstract

Keywords:
EchocardiographyHeart failureOutcomesStrain

More Related Videos

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking07:21

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Published on: February 12, 2011

14.9K
Evaluation of Left Ventricular Structure and Function using 3D Echocardiography06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

4.7K

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.2K
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
351
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
496
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
814