Related Experiment Video

Updated: Mar 5, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

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Asymptomatic Left Bundle Branch Block Predicts New-Onset Congestive Heart Failure and Death From Cardiovascular

Peyman N Azadani1, Ata Soleimanirahbar2, Gregory M Marcus2

  • 1Penn State Hershey Medical Center, PA, USA.

Cardiology Research
|March 30, 2017
PubMed

Insights

Left bundle branch block (LBBB) is linked to increased risk of new congestive heart failure (CHF) and cardiovascular death, even without prior heart disease. Early detection and intervention for LBBB may improve outcomes.

Area of Science:

  • Cardiology
  • Electrocardiography
  • Public Health

Background:

  • Left bundle branch block (LBBB) is a potential risk factor for cardiovascular morbidity and mortality.
  • The association requires further characterization in individuals without pre-existing heart conditions.

Purpose of the Study:

  • To assess the association between LBBB and new-onset congestive heart failure (CHF) or cardiovascular death.
  • To investigate LBBB as a predictor in a population free of clinical heart disease.

Main Methods:

  • The study analyzed 1,688 participants (>55 years) from the community-based SPPARCS cohort.
  • ECGs and medical history were collected every 2 years for 6 years.
  • LBBB at baseline or year 2 predicted CHF and cardiovascular death at years 4 and 6.

Main Results:

  • The prevalence of LBBB at baseline was 2.5% (42 participants).
  • LBBB was associated with a significantly higher incidence of new CHF (OR: 2.85, P=0.047) and cardiovascular death (OR: 2.35, P=0.044) after adjusting for confounders.
  • These associations persisted even in the absence of clinically detectable heart disease.

Conclusions:

  • Asymptomatic LBBB is associated with increased risk of new-onset CHF and cardiovascular mortality.
  • Further research is needed to explore diagnostic testing and early treatment strategies for asymptomatic LBBB to reduce cardiovascular events.
Abstract

Keywords:
Bundle-branch blockHeart failureMortalityRisk factors

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