Related Experiment Video
Updated: Mar 5, 2026
10:03
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
5.9K
The Relationship Between Plasma Eosinophil Count and Coronary Artery Ectasia
Mehmet Demir1, Serdar Keceoglu1, Mehmet Melek1
1Bursa Yuksek Ihtisas Education and Research Hospital Cardiology Department, Bursa, Turkey.
Cardiology Research
|March 30, 2017
Summary
Coronary artery ectasia (CAE) patients show higher eosinophil counts, neutrophil-lymphocyte ratio (NLR), and mean platelet volume (MPV) compared to controls. This suggests a link between these markers and CAE, aiding in understanding the condition.
Area of Science:
- Cardiology
- Hematology
- Inflammation Research
Background:
- The underlying causes of coronary artery ectasia (CAE) remain unclear, despite associations with arteritis, endothelial dysfunction, and atherothrombosis.
- Eosinophils are implicated in inflammatory and thrombotic processes, and vascular anomalies are observed in hypereosinophilic syndromes.
Purpose of the Study:
- To investigate the potential role of eosinophils in CAE by comparing eosinophil counts in CAE patients versus a control group.
- To explore associations between CAE and other hematological parameters like neutrophil-lymphocyte ratio (NLR) and mean platelet volume (MPV).
Main Methods:
- A cohort of 50 patients with CAE and 30 healthy controls were analyzed.
- Routine biochemical tests, complete blood counts (including neutrophil, lymphocyte, and eosinophil counts), and mean platelet volume (MPV) were performed concurrently.
Main Results:
- CAE patients exhibited significantly higher MPV, eosinophil counts, and NLR compared to controls.
- Statistical significance was observed for MPV (P < 0.001), eosinophil count (P = 0.002), and NLR (P = 0.028).
Conclusions:
- The study identified a significant relationship between elevated eosinophil counts, NLR, and MPV in patients diagnosed with CAE.
- These findings suggest that eosinophils and associated inflammatory markers may play a role in the pathophysiology of coronary artery ectasia.
Related Concept Videos
01:26Coronary Artery Disease II: Pathophysiology
838
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
838
01:30Acute Coronary Syndrome III: Diagnostic Studies
351
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
351
01:30Coronary Artery Disease I: Introduction
1.4K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.4K
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
636
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
636
01:30Acute Coronary Syndrome I: Introduction
1.3K
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
1.3K
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
582
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
582