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Endometrial cancer and microsatellite instability status
Daiva Kanopiene1, Jolanta Vidugiriene2, Konstantinas Povilas Valuckas3
1Out Patient Clinic, National cancer institute, Santariskiu 1, LT-08660, Vilnius, Lithuania.
Open Medicine (Warsaw, Poland)
|March 30, 2017
Summary
Microsatellite instability (MSI) is linked to deeper invasion and higher grade in endometrioid endometrial cancer. This finding helps identify potential markers for defective DNA repair in this cancer type.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Microsatellite instability (MSI) is a biomarker for DNA mismatch repair deficiency.
- MSI plays a role in the pathogenesis of various cancers, including endometrial cancer.
Purpose of the Study:
- To investigate the association between MSI status and clinicopathologic characteristics in endometrioid endometrial adenocarcinoma.
- To determine if MSI status can serve as a predictive marker in this specific cancer subtype.
Main Methods:
- MSI status was analyzed in 109 endometrial carcinomas using the Promega MSI Analysis System.
- The system employed 5 mononucleotide markers (BAT-25, BAT-26, NR-21, NR-24, MONO-27) and 2 pentanucleotide markers (Penta C, Penta D).
Main Results:
- Endometrioid histology was observed in 92% (100/109) of cases.
- MSI-high was identified in 17% (17/100) of endometrioid adenocarcinomas, but not in non-endometrioid types (0/9).
- MSI-high status correlated with deep myometrial invasion and higher histologic grade in endometrioid adenocarcinomas.
Conclusions:
- MSI status is associated with specific clinicopathologic features in endometrioid endometrial adenocarcinoma.
- These findings suggest MSI status may be a relevant factor in understanding endometrial cancer progression.
