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Use of antiviral therapy in patients with chronic hepatitis C

Natalia Dragomiretskaya1, Anna Izha1, Nikolay Kalinichenko1

  • 1Ukrainian scientific research institute of medical rehabilitation and curortology Ministry of Health Ukraine, Odessa, Ukraine.

Open Medicine (Warsaw, Poland)
|March 30, 2017
PubMed

Insights

This study shows that combining antiviral therapy with resort treatments effectively manages chronic hepatitis C (HCV) replication. Patients receiving combined therapy achieved higher rates of viral elimination and sustained remission compared to controls.

Area of Science:

  • Hepatology
  • Virology
  • Gastroenterology

Background:

  • Chronic hepatitis C (HCV) infection is prevalent and poses significant health risks.
  • Understanding HCV replication dynamics is crucial for effective treatment strategies.

Purpose of the Study:

  • To evaluate the efficacy of combined antiviral therapy (Roferon + Vero-Ribavirin) and resort treatments for chronic hepatitis C patients in the replication phase.
  • To assess the impact of this combined approach on viral clearance and clinical remission.

Main Methods:

  • A study involving 48 patients with chronic hepatitis C in the replication phase.
  • Utilized enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) for HCV detection and genotyping.
  • Therapy outcomes were monitored at multiple time points up to 12 months post-treatment.

Main Results:

  • All patients achieved persistent clinical and biochemical remission at 12 months.
  • Viral elimination was observed in 74% of the study group, compared to 56% in the control group.
  • The replication phase was associated with asthenic-vegetative syndrome, depression, pain, dyspepsia, hypertransaminasemia, and cholestasis.

Conclusions:

  • Combined antiviral therapy and resort treatment is effective for managing chronic hepatitis C in the replication phase.
  • This approach leads to improved viral clearance and sustained remission.
  • Addressing associated symptoms like asthenic-vegetative syndrome is important in HCV management.
Abstract

Keywords:
Antiviral therapychronic hepatitis Chealth resort factors

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