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Cranial and Spinal Meninges

Cranial and Spinal Meninges

The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...

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Updated: Mar 5, 2026

Glioblastoma Relapse Post-Resection Model for Therapeutic Hydrogel Investigations

Glioblastoma Relapse Post-Resection Model for Therapeutic Hydrogel Investigations

Published on: February 24, 2023

Meningioma recurrence.

Tibor Hortobágyi¹, János Bencze², Gréta Varkoly²

¹Division of Neuropathology, Institute of Pathology, University of Debrecen, Debrecen, Nagyerdei krt. 98., H-4032, Hungary.

Open Medicine (Warsaw, Poland)

|March 30, 2017

Summary

This summary is machine-generated.

Meningiomas, common brain tumors, can recur after surgery. Identifying risk factors through multidisciplinary collaboration is key for better treatment and fewer complications.

Keywords:

Genetics Immunohistochemistry Meningioma Molecular biology Neuropathology Pathology Prognostic factors Recurrence

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Area of Science:

Neurosurgery
Oncology
Pathology

Background:

Meningiomas constitute over 30% of intracranial tumors, predominantly affecting individuals over 60 with a 3:2 female-to-male ratio.
Tumor prognosis varies significantly, with WHO grade 1 tumors generally having a favorable outlook, while atypical (grade 2) and anaplastic (grade 3) meningiomas exhibit greater heterogeneity and risk.
Tumor size and location can lead to severe consequences, and recurrence or grade progression can occur even after surgical removal.

Purpose of the Study:

To review and synthesize current knowledge on factors predisposing to meningioma recurrence.
To highlight the limited understanding of histomorphological and molecular factors influencing recurrence.
To emphasize the need for a multidisciplinary approach in recognizing subtle signs of increased recurrence risk.

Main Methods:

Review of existing literature on meningioma recurrence.
Classification of predisposing factors into demographic, environmental, genetic/epigenetic, imaging, neuropathological, and neurosurgical categories.
Emphasis on the importance of collaborative expert review.

Main Results:

Knowledge regarding predisposing factors for meningioma recurrence remains limited.
Recurrence risk is influenced by a complex interplay of various factors.
Subtle signs indicating increased risk often require specialized expertise.

Conclusions:

A comprehensive understanding of meningioma recurrence requires integrating diverse data from multiple medical specialties.
Multidisciplinary collaboration is essential for accurate risk assessment and improved patient outcomes.
Enhanced understanding and early identification of recurrence risk factors can lead to more effective therapeutic strategies and reduced complications.