Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

8.3K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
8.3K
Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

5.5K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
5.5K
Neural Regulation01:37

Neural Regulation

43.8K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.8K
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

798
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
798
Brain Imaging01:14

Brain Imaging

821
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
821
Protein Networks02:26

Protein Networks

4.6K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The final appointment: risk factors and prevention of femicide.

Rivista di psichiatria·2026
Same author

The Hidden Architecture of Brain Structural Variability in 22q11.2 Deletion Syndrome: A Multi-site Study.

medRxiv : the preprint server for health sciences·2026
Same author

Understanding Schizophrenia Pathophysiology via fMRI-Based Information Theory and Multiplex Network Analysis.

Entropy (Basel, Switzerland)·2026
Same author

[The unhealable wounds of war: epigenetic and intergenerational damage.]

Rivista di psichiatria·2025
Same author

[Assisted suicide for patients suffering from severe depression. An unacceptable option that psychiatrists must fight with all their strength.]

Rivista di psichiatria·2025
Same author

Phenotypic traits and family history in patients with 22q11.2 deletion syndrome and generalized epilepsy: A multicenter case-control study.

Epilepsia·2024
Same journal

Normalization method for relative cerebral blood flow influences sex and cognitive status effects in nondemented older adults.

Brain imaging and behavior·2026
Same journal

Lack of association of the 5-HTTLPR polymorphism and brain serotonin transporter or receptor in healthy individuals: bayesian and frequentist meta-analyses.

Brain imaging and behavior·2026
Same journal

Prediction modeling in transdiagnostic risk: results from the PROCAN study.

Brain imaging and behavior·2026
Same journal

Impact of modifiable lifestyle factors on dementia subtypes and brain structural changes across KDIGO risk categories in the UK biobank.

Brain imaging and behavior·2026
Same journal

Disrupted white matter functional connectivity in post-stroke cognitive impairment: Insights from resting-state fMRI.

Brain imaging and behavior·2026
Same journal

Neural correlates of acceptance and commitment therapy in major depressive disorder: a task-based fMRI study.

Brain imaging and behavior·2026
See all related articles

Related Experiment Video

Updated: Mar 5, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.9K

Negative functional brain networks.

Fabrizio Parente1, Marianna Frascarelli2, Alessia Mirigliani2

  • 1Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University of Rome, Via A. Borelli 50, 00161, Rome, Italy. fabrizio.parente@uniroma1.it.

Brain Imaging and Behavior
|March 30, 2017
PubMed
Summary
This summary is machine-generated.

Functional brain networks with negative connections exhibit unique topological features, differing from random networks. These negative networks show altered connectivity patterns in schizophrenia, suggesting a role in the disorder.

Keywords:
Anticorrelated networksFunctional connectivityNetwork analysisResting stateSchizophrenia

More Related Videos

Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

14.7K
Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.6K

Related Experiment Videos

Last Updated: Mar 5, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.9K
Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

14.7K
Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.6K

Area of Science:

  • Neuroimaging
  • Network Neuroscience
  • Psychiatry

Background:

  • Anticorrelations in functional magnetic resonance imaging (fMRI) are not fully understood but may have physiological significance.
  • Exploring negative functional brain networks offers insights into brain organization and potential alterations in neurological disorders.

Purpose of the Study:

  • To investigate the topology of functional brain networks characterized by negative edges.
  • To compare these networks in healthy subjects and individuals with schizophrenia.
  • To assess the impact of preprocessing methods (CompCorr vs. Global Signal Regression) on network analysis.

Main Methods:

  • Analysis of resting-state fMRI data from 8 healthy controls and 8 schizophrenic patients.
  • Characterization of functional brain networks using degree distribution, centrality, efficiency, and rich-club analysis.
  • Comparison of network properties between preprocessing methods and diagnostic groups.

Main Results:

  • Functional brain networks, including those with negative edges, display a truncated power-law degree distribution.
  • Negative edge networks exhibit disassortative properties (highly connected nodes link to fewer nodes), which are lost with Global Signal Regression.
  • Schizophrenia patients show decreased local and global efficiency and reduced connectivity among central nodes in negative networks.

Conclusions:

  • Functional brain networks with negative values possess distinct, non-random topological features.
  • These negative networks are implicated in the neurobiological alterations observed in schizophrenia.
  • Preprocessing choices significantly influence the characterization of negative functional brain networks.