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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

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Comparison of 18F-FDG-PET/CT and 18F-FDG-PET/MR imaging in oncology: a systematic review

Amit Singnurkar¹, Raymond Poon², Ur Metser³

¹Department of Nuclear Medicine and Molecular Imaging, Hamilton Health Sciences and St. Joseph's Healthcare Hamilton, 711 Concession Street, Hamilton, ON, L8V 1C3, Canada.

Annals of Nuclear Medicine

|March 30, 2017

Abstract

Objective:

The aim of this study was to systematically review the literature to evaluate the clinical performance of integrated ¹⁸F-FDG PET/MR as compared with ¹⁸F-FDG PET/CT in oncologic imaging.

Methods:

The literature was searched using MEDLINE and EMBASE via OVID. Studies comparing the diagnostic accuracy of integrated ¹⁸F-FDG PET/MR and ¹⁸F-FDG PET/CT in the diagnosis, staging/restaging, assessment of treatment response, or evaluation of metastasis in patients with suspected or diagnosed cancers were deemed eligible for inclusion. Risk of bias and applicability concerns were assessed using the QUADAS-2 tool.

Results:

Twenty studies met the inclusion criteria. The overall quality of the studies was rated favorably with bias or applicability concerns in a few studies. Our review suggests that ¹⁸F-FDG PET/MR performs comparably to ¹⁸F-FDG PET/CT in the detection of local lymph node and distant metastases and superiorly in determining the local extent of tumor. SUV obtained from ¹⁸F-FDG PET/MR correlated highly with those obtained from ¹⁸F-FDG PET/CT.

Conclusions:

Based on early evidence, ¹⁸F-FDG PET/MR is comparable to ¹⁸F-FDG PET/CT in the clinical scenarios examined in this review. The potential for interchangeability of ¹⁸F-FDG PET/MR with ¹⁸F-FDG PET/CT will vary by indication and the body site that is being imaged, with PET scanners integrated with MRI predicted to provide greater detail in the evaluation of local tumor extent, where ¹⁸F-FDG PET/CT can be limited.

Keywords:

FDG Multimodal imaging Oncology PET/CT PET/MR

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