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Fluorescent probes sensitive to changes in the cholesterol-to-phospholipids molar ratio in human platelet membranes
1Institute of Chemistry, V.N. Karazin Kharkiv National University, Kharkiv 61022, Ukraine.
Methods and Applications in Fluorescence
|March 30, 2017
Abstract:
Environment-sensitive fluorescent probes were used for the spectroscopic visualization of pathological changes in human platelet membranes during cerebral atherosclerosis. It has been estimated that the ratiometric probes 2-(2'-hydroxyphenyl)-5-phenyl-1,3,4-oxadiazole and 2-phenyl-phenanthr[9,10]oxazole can detect changes in the cholesterol-to-phospholipids molar ratio in human platelet membranes during the disease.
