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The Sirt6 gene: Does it play a role in tooth development?
Xueyang Liao1, Bo Feng1, Demao Zhang1
1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Plos One
|March 30, 2017
Summary
Sirtuin-6 (SIRT6) deletion in mice delayed tooth eruption and root development by affecting dental mesenchymal cell differentiation. This highlights SIRT6
Area of Science:
- Molecular Biology
- Developmental Biology
- Cell Biology
Background:
- Dental Mesenchymal Cells (DMCs) are crucial for tooth development and regeneration.
- Sirtuin-6 (SIRT6), a key aging regulator, influences stem cell differentiation.
- The role of SIRT6 in tooth development was previously unexplored.
Purpose of the Study:
- To investigate the role of Sirtuin-6 (SIRT6) in tooth development and dental mesenchymal cell (DMC) differentiation.
- To explore the molecular mechanisms underlying SIRT6's function in odontogenesis.
Main Methods:
- Utilized Sirt6 knockout (Sirt6-/-) mice to study post-natal tooth development.
- Analyzed DMC proliferation, adipogenic, osteogenic, and chondrogenic differentiation in vitro.
- Investigated signaling pathways including NF-κB, p38-MAPK, ERK, and mitochondrial energy.
Main Results:
- Sirt6 deletion did not affect pre-natal tooth development but caused delayed tooth eruption and impaired root development post-natally.
- Sirt6 deletion enhanced DMC proliferation and adipogenic differentiation while inhibiting osteogenic/chondrogenic differentiation.
- SIRT6 expression was detected in mouse odontoblasts, suggesting a direct role.
Conclusions:
- Sirtuin-6 (SIRT6) is essential for normal post-natal tooth root formation and eruption.
- SIRT6 regulates dental mesenchymal cell (DMC) differentiation, impacting tooth development.
- SIRT6 influences odontogenesis through pathways like NF-κB, p38-MAPK, ERK, and mitochondrial energy.
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