90-kDa N-domain angiotensin I-converting enzyme (ACE): possible marker for hypertension in a renal transplant model
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Cleber A Leite1, Nádia Sc Bertoncello1, Ingrid Km Watanabe1
1Universidade Federal de São Paulo, Brazil.
Introduction:
Hypertension is nearly universal in kidney transplant and several factors are associated with post transplant hypertension, including immunosuppressive medications and genetic predisposition.
Objective:
The aims were to evaluate the effects of spontaneously hypertensive rats (SHR) kidney transplantation in Wistar rats and the possible transference of 80/90-kDa N-domain ACE.
Methods:
To do so, the data from Wistar recipients of kidney from SHR were compared to data from transplanted Wistar submitted to CsA treatment and, to Wistar Sham.
Results And Discussion:
Despite the unaltered blood pressure observed at early stages, 80/90-kDa ACE was found expressed in the urine of rats 7 and 15 days after transplantation, which was intense when rats became hypertensive 30 days post-surgery.
Conclusion:
Our data show that this enzyme is associated with the development of hypertension, and this marker appears in the urine before any substantial blood pressure alteration.