Bidirectional synaptic plasticity can explain bidirectional retrograde effects of emotion on memory
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Bryan A Strange1, Ana Galarza-Vallejo1
1Laboratory for Clinical Neuroscience,Centro de Tecnología Biomédica,Universidad Politecnica de Madrid,Pozuelo de Alarcón,Madrid 28223,Spainbryan.strange@upm.esana.galarza@ctb.upm.eswww.thestrangelab.org.
The Behavioral and Brain Sciences
|March 31, 2017
Abstract:
Emotional events can either impair or enhance memory for immediately preceding items. The GANE model explains this bidirectional effect as a glutamate "priority" signal that modulates noradrenaline release depending on arousal state. We argue for an alternative explanation: that priority itself evokes phasic noradrenaline release. Thus, contrasting E-1 memory effects are explained by a mechanism based on the Bienenstock-Cooper-Munro theory.