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Related Experiment Videos

Pathophysiological Implications of Dipeptidyl Peptidases.

Akira Sato1, Hisakazu Ogita2

  • 1Division of Molecular Medical Biochemistry, Department of Biochemistry and Molecular Biology, Shiga University of Medical Science, Otsu 520-2192. Japan.

Current Protein & Peptide Science
|March 31, 2017
PubMed
Summary

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Dipeptidyl peptidases (DPPs) are proteases involved in peptide processing. While DPP 4 is widely studied for metabolic and immune roles, other DPPs like DPP 3 show therapeutic potential.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Enzymology

Background:

  • Dipeptidyl peptidases (DPPs) are a family of proteases (EC 3.4.14) with eight mammalian members.
  • DPPs are crucial for N-terminal oligopeptide processing and bioactive peptide degradation.
  • Research has predominantly focused on DPP 4 due to its roles in metabolism and immunity, leading to approved drugs for type 2 diabetes and obesity.

Purpose of the Study:

  • To review the pathophysiological functions of the Dipeptidyl peptidase (DPP) family.
  • To explore the therapeutic potential of DPP family members beyond DPP 4.
  • To identify novel pharmacological targets within the DPP family.

Main Methods:

  • Literature review of existing research on DPP family functions.
  • Analysis of pathophysiological roles of various DPP members.
Keywords:
Dipeptidyl peptidaseangiotensinbioactive peptideshypertensionimmune regulationmetabolic disease

Related Experiment Videos

  • Discussion of current and future therapeutic applications of DPPs.

    • Main Results:

    • DPP 4 inhibitors are established treatments for type 2 diabetes and obesity.
    • Emerging research highlights the significance of other DPPs, such as DPP 3, in various physiological and pathological processes.
    • The DPP family presents diverse opportunities for novel therapeutic strategies.

    Conclusions:

    • The Dipeptidyl peptidase (DPP) family, beyond DPP 4, holds significant promise for future drug development.
    • Further investigation into DPP 3 and other family members could yield novel therapeutic agents.
    • DPPs represent a valuable class of targets for pharmacological intervention in various diseases.