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Evaluation of two socket healing procedures with and without mesenchymal stem cells: A comparative study
Abhinav Jain1, Mahinder Singh1, K P Ganapathy2
1Department of Oral and Maxillofacial Surgery, Uttaranchal Dental and Medical Research Institute, Dehradun, Uttarakhand, India.
National Journal of Maxillofacial Surgery
|March 31, 2017
Summary
Mesenchymal stem cells (MSCs) on collagen membranes effectively preserved alveolar ridge width after tooth extraction, reducing the need for future augmentation procedures. This socket preservation technique shows promising results for maintaining ridge dimensions.
Area of Science:
- Regenerative Dentistry
- Oral Surgery
- Biomaterials Science
Background:
- Alveolar ridge preservation after tooth extraction is crucial to prevent bone loss and facilitate future dental restorations.
- Traditional bone grafting methods can be invasive and may not always achieve optimal ridge dimensions.
- Mesenchymal stem cells (MSCs) offer regenerative potential for tissue healing and bone formation.
Purpose of the Study:
- To evaluate the efficacy of a novel ridge preservation technique using MSCs seeded on a collagen membrane.
- To objectively assess the maintenance of alveolar ridge width and height following tooth extraction.
Main Methods:
- Ten patients with bilaterally symmetrical extraction sockets were included.
- Extraction sockets were treated with either MSCs on a collagen membrane (test group) or a collagen membrane alone (control group).
- Alveolar ridge dimensions (buccolingual and mesiodistal widths) were measured immediately post-extraction and at 3 and 6 months.
Main Results:
- A statistically significant difference was observed in maintaining alveolar ridge width in the MSC-grafted sites compared to the control sites.
- The use of MSCs seeded on collagen membranes demonstrated superior ridge width preservation.
Conclusions:
- Socket healing utilizing MSCs combined with a collagen membrane is a successful method for preserving alveolar ridge width.
- This technique shows potential for reducing or eliminating the need for subsequent ridge augmentation procedures.