Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Drug Development Against Metastatic Cancers.

Chen Wang¹, Sui Huang¹

¹Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, IL.

The Yale Journal of Biology and Medicine

|March 31, 2017

Summary

Metastatic cancer, a major cause of cancer death, requires new treatments beyond tumor growth inhibition. This review explores past, current, and future anti-cancer drug development strategies to combat cancer metastasis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Hemodynamic effects of synchronous and asynchronous independent lung ventilation with different levels of positive end-expiratory pressure and tidal volumes on unilateral lung injury in dogs].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2010

Same author

[Study on the immuno-effects and influencing factors of Chinese hamster ovary (CHO) cell hepatitis B vaccine among adults, under different dosages].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2010

Same author

Assemblies of fluorine containing bent-shaped liquid crystal molecules studied by using scanning tunneling microscopy.

Journal of nanoscience and nanotechnology·2010

Same author

Carbon nanotubes induce secondary structure changes of bovine albumin in aqueous phase.

Journal of nanoscience and nanotechnology·2010

Same author

[Immunogenicity and protective efficacy of pertactin recombinants against Bordetella bronchiseptica challenge].

Wei sheng wu xue bao = Acta microbiologica Sinica·2010

Same author

[Analysis of the electrocardiographic findings in 288 patients with acute pulmonary thromboembolism].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2010

Area of Science:

Oncology
Cancer Metastasis Research
Pharmacology

Background:

Despite advances in cancer diagnostics and treatments, metastatic cancer remains a primary cause of mortality.
The complexity of metastatic transformation, involving cellular and extracellular changes, hinders effective treatment.
Current anti-cancer drugs primarily inhibit tumor growth, but are insufficient to block metastasis.

Purpose of the Study:

To review the historical and current landscape of anti-cancer drug development.
To identify the limitations of existing therapeutic strategies against metastatic cancer.
To explore alternative approaches for future anti-cancer drug development targeting metastasis.

Main Methods:

Literature review of past and current anti-cancer drug development strategies.

Keywords:

anti-cancer drugs anti-metastasis metastasis treatment strategies

Related Experiment Videos

Analysis of the mechanisms of metastatic transformation.

Discussion of the efficacy and limitations of current treatments.

Main Results:

Established anti-cancer drugs are largely ineffective at preventing or treating cancer metastasis.
The complexity of metastasis necessitates novel therapeutic targets and strategies.
Current drug development focuses on tumor growth inhibition, neglecting the metastatic process.

Conclusions:

There is a critical need for novel therapeutic strategies to effectively combat cancer metastasis.
Future drug development should focus on targeting the mechanisms of metastasis, not just tumor growth.
Exploring alternative approaches is essential for improving survival rates in metastatic cancer patients.