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Improving data transparency in clinical trials using blockchain smart contracts.

Timothy Nugent1, David Upton2, Mihai Cimpoesu2

  • 1Corporate Research and Development, Thomson Reuters, London, UK.

F1000Research
|March 31, 2017
PubMed
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Blockchain smart contracts can enhance clinical trial integrity by preventing data manipulation. This technology acts as a trusted administrator, ensuring an immutable record of trial history and boosting scientific credibility.

Area of Science:

  • Biomedical research
  • Computer science
  • Blockchain technology

Background:

  • Clinical trial credibility is compromised by issues like missing data, endpoint switching, and selective publication, leading to distorted treatment perceptions.
  • Existing legislative interventions have had limited success in addressing these integrity issues.

Purpose of the Study:

  • To extend the use of blockchain technology in clinical trials.
  • To demonstrate how smart contracts can enforce trust and eliminate data manipulation in clinical research.

Main Methods:

  • Utilized blockchain smart contracts, which are self-executing code and data on a blockchain.
  • Employed cryptographic validation by the network to ensure the integrity of contract execution.
  • Established an immutable record of clinical trial history.
Keywords:
BlockchainClinical TrialsEthereumMissing DataSmart Contract

Related Experiment Videos

Main Results:

  • Demonstrated that blockchain smart contracts can serve as trusted administrators for clinical trials.
  • Showcased the elimination of data manipulation through the immutable record provided by smart contracts.
  • Validated the effectiveness of this technological solution in enforcing trust.

Conclusions:

  • Blockchain smart contracts offer a novel technological solution to combat data manipulation in clinical trials.
  • Implementation of smart contracts can significantly enhance the trustworthiness and reliability of clinical trial findings.
  • This approach provides an immutable and cryptographically secured record, bolstering scientific credibility.