Related Experiment Videos
Recent advances in understanding and managing gout
Talia F Igel1, Svetlana Krasnokutsky2, Michael H Pillinger2
1The Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY, USA; The School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia.
Insights
Gout, a common inflammatory arthritis, is often under-diagnosed and under-treated, leading to poor patient outcomes. Recent advances in diagnosis and novel therapies offer hope for improved gout management and quality of life.
Area of Science:
- Rheumatology
- Crystal Arthropathies
- Inflammatory Arthritis
Background:
- Gout is the most prevalent crystal arthropathy and a primary cause of inflammatory arthritis.
- It significantly impacts patients' quality of life, functional capacity, morbidity, and mortality.
- Despite treatment advances, gout remains under-diagnosed and under-treated, with high rates of poor disease control.
Purpose of the Study:
- To review recent advancements in the diagnosis and management of gout.
- To discuss novel therapeutic strategies for gout treatment.
- To highlight potential improvements in patient care and outcomes.
Main Methods:
- Literature review of recent studies on gout diagnosis and management.
- Analysis of novel urate-lowering therapies and imaging modalities.
- Discussion of updated understanding of gout pathogenesis.
Main Results:
- Gout significantly affects patient morbidity, mortality, and quality of life.
- A substantial percentage of gout patients experience suboptimal management and persistent hyperuricemia.
- Novel diagnostic tools and urate-lowering therapies are emerging.
Conclusions:
- Recent progress in understanding gout pathogenesis, diagnosis, and treatment offers opportunities for better patient care.
- Novel therapeutics and diagnostic approaches may lead to improved outcomes for individuals with gout.
- Addressing under-diagnosis and under-treatment is crucial for effective gout management.
Abstract:
Gout is the most common crystal arthropathy and the leading cause of inflammatory arthritis. It is associated with functional impairment and, for many, a diminished health-related quality of life. Numerous studies have demonstrated the impact of gout and its associated conditions on patient morbidity and mortality. Unfortunately, gout remains under-diagnosed and under-treated in the general community. Despite major advances in treatment strategies, as many as 90% of patients with gout are poorly controlled or improperly managed and their hyperuricemia and recurrent flares continue. The introduction of novel urate-lowering therapies, new imaging modalities, and a deeper understanding of the pathogenesis of gout raise the possibility of better gout care and improved patient outcomes. Here, we spotlight recent advances in the diagnosis and management of gout and discuss novel therapeutics in gout treatment.