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Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma
Published on: November 5, 2020
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Pancreatic neuroendocrine tumors
1Department of Hepatobiliary and Pancreatic Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Intractable & Rare Diseases Research
|March 31, 2017
Summary
Pancreatic neuroendocrine neoplasms (pNENs) are diverse tumors with increasing incidence. This review covers pNEN diagnosis, presentation, and treatment strategies for unresectable cases.
Area of Science:
- Oncology
- Gastroenterology
- Endocrinology
Background:
- Pancreatic neuroendocrine neoplasms (pNENs) encompass a spectrum of tumors, including pancreatic neuroendocrine tumors (pNETs) and neuroendocrine carcinomas (pNECs).
- There has been a notable rise in pNEN incidence over recent decades, accompanied by increased research interest.
- Despite advancements, classification and diagnostic criteria for pNENs remain subjects of ongoing discussion.
Purpose of the Study:
- To provide a comprehensive overview of pancreatic neuroendocrine neoplasms (pNENs).
- To detail the diagnostic work-up and clinical presentation of pNENs.
- To summarize current and emerging treatment options for pNENs, particularly for advanced or unresectable disease.
Main Methods:
- Literature review and synthesis of current research on pNENs.
- Analysis of diagnostic modalities and clinical staging for pNENs.
- Evaluation of therapeutic strategies, including surgical and non-surgical interventions.
Main Results:
- pNENs are a heterogeneous group requiring precise classification for optimal management.
- Early and accurate diagnosis is crucial for patient outcomes.
- Effective therapeutic strategies for advanced pNENs are still evolving, necessitating personalized treatment plans.
Conclusions:
- A clear understanding of pNEN classification and diagnosis is essential.
- Surgical resection is the primary treatment for resectable pNENs.
- Further research is needed to establish definitive treatment protocols for advanced and unresectable pNENs, addressing the current therapeutic uncertainties.
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