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Mnemons: encoding memory by protein super-assembly.

Fabrice Caudron1, Yves Barral1

  • 1Institute of Biochemistry, Department of Biology, ETH Zurich, Otto-Stern-Weg 3, 8093 Zurich, Switzerland.

Microbial Cell (Graz, Austria)
|March 31, 2017
PubMed
Summary
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Budding yeast cells exhibit a stable, mother-cell-specific memory after failed mating attempts. This cellular memory, akin to prion behavior, allows adaptation to environmental cues and offers insights into synaptic memory mechanisms.

Area of Science:

  • Cell Biology
  • Neuroscience
  • Genetics

Background:

  • Memory is traditionally viewed as human recollection, but can be observed in simpler organisms as adaptive behavioral changes.
  • Unicellular organisms demonstrate learning and memory by adapting responses to environmental stimuli, suggesting conserved mechanisms.

Purpose of the Study:

  • To explore memory mechanisms in unicellular organisms, specifically budding yeast.
  • To investigate the molecular basis of a stable, non-heritable cellular memory in yeast.
  • To compare yeast cellular memory with prion phenomena and synaptic memory in humans.

Main Methods:

  • Observing behavioral adaptation in budding yeast exposed to mating pheromone.
  • Analyzing the stability and inheritance patterns of the refractory state in yeast mother and daughter cells.
Keywords:
Whi3budding yeastmemorymnemonspheromone responsesuper-assemblies

Related Experiment Videos

  • Comparing the molecular mechanisms of yeast memory to prion biology.

    • Main Results:

    • Budding yeast cells develop a stable refractory state to mating pheromone after unsuccessful mating.
    • This refractory state is restricted to the mother cell and not passed to daughter cells.
    • The establishment and segregation of this cellular memory show analogies and differences to prions.

    Conclusions:

    • Cellular memory in yeast, characterized by stability and asymmetric inheritance, provides a model for understanding memory encoding.
    • The study highlights conserved principles of memory across different life forms, from yeast to humans.
    • Investigating yeast memory mechanisms can illuminate the complex molecular processes underlying synaptic plasticity and memory in the brain.