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Related Experiment Videos

Yeast as a tool to explore cathepsin D function.

H Pereira1, C S F Oliveira2, L Castro1

  • 1CBMA- Centre of Molecular and Environmental Biology. Department of Biology, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.

Microbial Cell (Graz, Austria)
|March 31, 2017
PubMed
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Cathepsin D, a protein implicated in human diseases, has dual roles in cell survival and death, especially in cancer. Understanding its regulation is key to developing new cancer therapies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Cathepsin D is increasingly recognized for its association with various human pathologies.
  • Overexpression and hypersecretion of Cathepsin D in cancer cells suggest its potential as a therapeutic target.
  • Cathepsin D exhibits context-dependent anti- and pro-survival functions, necessitating a deeper understanding of its regulation.

Purpose of the Study:

  • To review the physiological and pathological roles of Cathepsin D.
  • To elucidate the opposing functions of Cathepsin D in apoptosis, with a focus on cancer research.
  • To explore how yeast Cathepsin D (Pep4p) insights can inform mammalian Cathepsin D research.

Main Methods:

  • Literature review of Cathepsin D's role in physiological and pathological conditions.
Keywords:
apoptosiscancercathepsin Dyeast cathepsin Dyeast model

Related Experiment Videos

  • Analysis of Cathepsin D's dual functions in apoptosis and cell death pathways.
  • Comparative study of mammalian Cathepsin D and its yeast homolog, Pep4p.

    • Main Results:

    • Cathepsin D plays a significant role in both normal physiological processes and various human diseases.
    • The protein demonstrates complex, often opposing, effects on apoptosis, acting as both a pro- and anti-survival factor.
    • The yeast vacuolar protease Pep4p, a functional counterpart to Cathepsin D, influences cell life and death, offering comparative insights.

    Conclusions:

    • A comprehensive understanding of Cathepsin D's regulatory mechanisms and its modulation of apoptotic functions is crucial.
    • Insights from yeast Cathepsin D research can potentially uncover novel functions of mammalian Cathepsin D in apoptosis.
    • Further investigation into Cathepsin D is warranted for its therapeutic potential in cancer and other pathologies.