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Mitochondrial regulation of cell death: a phylogenetically conserved control
Lorenzo Galluzzi1,2,3,4,5, Oliver Kepp1,2,3,4,6, Guido Kroemer1,2,3,4,6,7,8
1Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France.
Microbial Cell (Graz, Austria)
|March 31, 2017
Abstract:
Mitochondria are fundamental for eukaryotic cells as they participate in critical catabolic and anabolic pathways. Moreover, mitochondria play a key role in the signal transduction cascades that precipitate many (but not all) regulated variants of cellular demise. In this short review, we discuss the differential implication of mitochondria in the major forms of regulated cell death.