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A bidirectional synthesis of spiroacetals via Rh(ii)-catalysed C-H insertion
Romain J Lepage1, Jonathan M White, Mark J Coster
1Griffith Institute for Drug Discovery (GRIDD), Griffith University, Don Young Rd, Nathan, Queensland 4111, Australia. m.coster@griffith.edu.au.
Chemical Communications (Cambridge, England)
|March 31, 2017
Abstract:
Acyclic methylene acetals bearing two diazoester subunits have been converted to [5,5]-spiroacetals via bidirectional C-H insertion under Rh(ii) catalysis. Using a chiral Rh(ii) catalyst, the major diastereomer can be produced in high enantiomeric excess (89%).