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Updated: Jun 28, 2026

Whole Mount Immunolabeling of Olfactory Receptor Neurons in the Drosophila Antenna
Published on: May 4, 2014
Mechanisms controlling diversification of olfactory sensory neuron classes
Yi-Wen Hsieh1, Amel Alqadah1, Chiou-Fen Chuang2
1Department of Biological Sciences, University of Illinois at Chicago, 900 S. Ashland Avenue, MC 567, Chicago, IL, 60607, USA.
Abstract:
Animals survive in harsh and fluctuating environments using sensory neurons to detect and respond to changes in their surroundings. Olfactory sensory neurons are essential for detecting food, identifying danger, and sensing pheromones. The ability to sense a large repertoire of different types of odors is crucial to distinguish between different situations, and is achieved through neuronal diversity within the olfactory system. Here, we review the developmental mechanisms used to establish diversity of olfactory sensory neurons in various model organisms, including Caenorhabditis elegans, Drosophila, and vertebrate models. Understanding and comparing how different olfactory neurons develop within the nervous system of different animals can provide insight into how the olfactory system is shaped in humans.
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