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v-jun is a transcriptional activator, but not in all cell-lines
J L Imler1, E Ugarte, C Wasylyk
1Laboratoire de Génétique Moléculaire des Eucaryotes, CNRS, Strasbourg, France.
Nucleic Acids Research
|April 11, 1988
Abstract:
The recently isolated v-jun oncogene encodes a protein with sequence homology to the transcription factor AP1, as well as a similar DNA binding specificity. We show, by expressing v-jun in F9 embryocarcinoma cells, that v-jun is also a transcriptional activator. However, v-jun expression does not activate transcription in several other cell-lines, suggesting that cell-specific factors are required for v-jun activity.