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Setting Ideal Lubricant Mixing Time for Manufacturing Tablets by Evaluating Powder Flowability
Shohei Nakamura1, Saori Yamaguchi2, Rikiha Hiraide2
1Department of Pharmaceutical Technology, School of Clinical Pharmacy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime, 790-8578, Japan. snakamur@g.matsuyama-u.ac.jp.
AAPS Pharmscitech
|March 31, 2017
Summary
Carr
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Optimizing tablet manufacturing requires precise control over powder properties.
- Magnesium stearate (Mg-St) concentration and mixing time significantly impact powder flow and tablet quality.
Purpose of the Study:
- To evaluate Carr's flowability index (FI) and angle of internal friction (Φ) for predicting tablet physical properties.
- To establish Mg-St mixing time targets for achieving desired tablet characteristics.
Main Methods:
- Investigated powder flowability (FI and Φ) under varying Mg-St concentrations and mixing times.
- Correlated powder flowability with tablet properties (weight variation, content uniformity, hardness, friability, disintegration).
Main Results:
- Mg-St mixing time strongly correlated with powder FI (R² = 0.883).
- Powder FI showed significant correlations with tablet weight variation (R² = 0.509), hardness (R² = 0.525), and friability (R² = 0.477).
Conclusions:
- Carr's FI of pharmaceutical powder effectively predicts tablet physical properties.
- Using FI to set Mg-St mixing time enables targeted tablet manufacturing, reducing the need for trial tableting.