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Related Experiment Videos

Functional Silver-Coated Colloidosomes as Targeted Carriers for Small Molecules.

Qian Sun1, Yao Du1, Ziyan Zhao1

  • 1Department of Chemical Engineering and Biotechnology, University of Cambridge , Pembroke Street, CB2 3RA Cambridge, United Kingdom.

Langmuir : the ACS Journal of Surfaces and Colloids
|March 31, 2017
PubMed
Summary

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Researchers developed novel silver-coated colloidosomes for drug delivery. These impermeable capsules offer targeted release via ultrasound, overcoming limitations of traditional polymer shells for medical applications.

Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Colloidosomes are promising for drug storage and delivery.
  • Conventional polymer colloidosomes exhibit permeability, leading to drug leakage.
  • Need for impermeable carriers with controlled release mechanisms.

Purpose of the Study:

  • To engineer novel silver-coated colloidosomes with enhanced impermeability and controlled release capabilities.
  • To functionalize silver colloidosomes for specific biological targeting.
  • To investigate ultrasound-triggered shell disruption for drug release.

Main Methods:

  • Fabrication of aqueous core colloidosomes with a silver shell via reaction of l-ascorbic acid and silver nitrate.
  • Surface modification using 4,4'-dithiodibutyric acid and cross-linking with rabbit Immunoglobulin G (IgG).

Related Experiment Videos

  • Label-free surface plasmon resonance for immunoassay targeting validation and ultrasound for shell disruption.

    • Main Results:

    • Successfully created impermeable silver shell colloidosomes.
    • Demonstrated specific targeting of functionalized silver shells with rabbit antigen using surface plasmon resonance.
    • Confirmed ultrasound-induced shell breakage for potential drug release.

    Conclusions:

    • Developed a new class of silver-coated colloidosomes with immunoassay targeting, impermeability, and ultrasound sensitivity.
    • These functional colloidosomes show significant potential for diverse medical and pharmaceutical applications.
    • Overcomes limitations of traditional polymer colloidosomes for drug delivery.