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Ru(II)-Catalyzed C-H Functionalization on Maleimides with Electrophiles: A Demonstration of Umpolung Strategy
Suman Dana1, Anup Mandal1, Harekrishna Sahoo1
1Department of Chemistry, Indian Institute of Technology Madras , Chennai 600 036, Tamil Nadu, India.
Organic Letters
|March 31, 2017
Abstract:
The unconventional nucleophilic reactivity of maleimides, innate electrophiles, has been realized under Ru(II)-catalysis such that exposure to electrophiles delivered products of C-H chalcogenation and amidation in good yields (up to 94%). This protocol features mild conditions and operational simplicity with broad substrate scope, uses an inexpensive and air-stable catalyst, and also represents the first example of Ru(II) catalyzed C-H selenylation of alkenes.