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Related Concept Videos

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A Finite Element Approach for Locating the Center of Resistance of Maxillary Teeth
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External apical root resorption concurrent with orthodontic forces: the genetic influence.

Nuria Nieto-Nieto1, Jose Enrique Solano1, Rosa Yañez-Vico1

  • 1a Department of Stomatology , School of Dentistry, University of Seville , Seville , Spain.

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Summary

Genetic factors influence external apical root resorption (EARR) during orthodontic treatment. Understanding these genetic biomarkers may help prevent or reduce EARR occurrence in patients undergoing orthodontic care.

Keywords:
External apical root resorptionaetiologygeneticsorthodontic treatmentorthodontics

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Area of Science:

  • Dental research
  • Genetics
  • Orthodontics

Background:

  • External apical root resorption (EARR) is a common complication of orthodontic tooth movement.
  • Genetic predisposition and environmental factors contribute to EARR susceptibility.
  • Previous studies have identified several genetic biomarkers associated with EARR.

Purpose of the Study:

  • To review and analyze current information on the genetic factors predisposing to EARR during orthodontic treatment.
  • To consolidate findings from genetics-based studies and basic science research.
  • To elucidate the role of genetic inheritance in EARR development.

Main Methods:

  • Literature review of genetics-based studies.
  • Analysis of research on genetic biomarkers influencing EARR.
  • Compilation of data on gene clusters and specific genes (e.g., IL1, OPG, RANK).

Main Results:

  • Several genetic biomarkers, including IL1 gene cluster, P2RX7, CASP1, TNFRSF11B (OPG), TNFRSF11A (RANK), Osteopontin, TNFα, vitamin D receptor, TNSALP, and IRAK1, have been investigated for their influence on EARR.
  • These genetic variations can confer varying degrees of susceptibility or resistance to EARR.
  • Genetic predisposition is recognized as a significant etiological factor alongside mechanical stimuli.

Conclusions:

  • Genetic background plays a crucial role in the development of EARR during orthodontic treatment.
  • Further research integrating genetic and basic science findings is needed to fully understand EARR.
  • Identifying genetic predispositions could lead to strategies for preventing or eradicating EARR in orthodontic patients.