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Related Experiment Videos

Default mode functional connectivity is associated with social functioning in schizophrenia.

Jaclyn M Fox1, Samantha V Abram2, James L Reilly1

  • 1Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University.

Journal of Abnormal Psychology
|March 31, 2017
PubMed
Summary
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Default mode network (DMN) connectivity was not different between schizophrenia patients and controls. However, fronto-parietal DMN connectivity related to social functioning in schizophrenia patients, suggesting its potential as a neuroimaging marker.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Science

Background:

  • Schizophrenia is characterized by significant social functioning deficits.
  • Default mode network (DMN) connectivity is linked to social cognition and functioning in various populations.
  • The relationship between DMN connectivity, social cognition, and social functioning in schizophrenia remains understudied.

Purpose of the Study:

  • To investigate DMN connectivity between medial prefrontal cortex (mPFC) and posterior cingulate cortex-anterior precuneus (PPC) in schizophrenia.
  • To examine the association between DMN connectivity and social functioning (social attainment, social competence).
  • To determine if social cognition mediates the DMN connectivity-social functioning relationship in schizophrenia.

Main Methods:

Related Experiment Videos

  • Resting-state neuroimaging data analyzed for DMN connectivity in individuals with schizophrenia (n=28) and controls (n=32).
  • Social functioning assessed using the Specific Levels of Functioning Scale and Social Skills Performance Assessment.
  • Statistical analyses explored group differences, connectivity associations, and mediation effects.

    • Main Results:

    • No significant differences in overall DMN connectivity between schizophrenia patients and controls.
    • A significant group-by-connectivity interaction revealed that mPFC-PPC connectivity was associated with social competence and attainment in schizophrenia but not controls.
    • Social cognition did not mediate the relationship between DMN connectivity and social functioning.

    Conclusions:

    • Fronto-parietal DMN connectivity may be differentially associated with social functioning in schizophrenia compared to controls.
    • DMN connectivity shows potential as a neuroimaging biomarker for treatment response monitoring in schizophrenia.
    • Targeting DMN connectivity could be a therapeutic strategy to improve social functioning in schizophrenia.