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Effects of L-thyroxine treatment on heart functions in infants with congenital hypothyroidism

Alev Arslan1, Veysel Nijat Baş2, Salih Uytun3

  • 1Division of Pediatric Cardiology Başkent University Faculty of Medicine, Adana Dr. Turgut Noyan Medical and Research Center, Adana.

Journal of Pediatric Endocrinology & Metabolism : JPEM
|March 31, 2017
PubMed

Insights

Congenital hypothyroidism (CH) in newborns can impair heart function. Early levothyroxine (L-T4) treatment can reverse this diastolic dysfunction, as shown by echocardiography.

Area of Science:

  • Neonatal cardiology
  • Pediatric endocrinology

Background:

  • Congenital hypothyroidism (CH) can impair cardiac function in newborns.
  • Levothyroxine (L-T4) substitution therapy is crucial for reversing these effects.

Purpose of the Study:

  • To investigate cardiac function in neonates with CH using echocardiography.
  • To assess changes in heart function after initiating L-T4 therapy.

Main Methods:

  • Included 30 neonates with CH and 34 healthy controls.
  • Utilized conventional and tissue Doppler echocardiography at baseline, 2 weeks, and 6 months.
  • Measured parameters including mitral E velocities, mitral E/A ratios, and Tei indices.

Main Results:

  • Neonates with CH showed lower mitral E velocities and mitral E/A ratios at baseline.
  • Tei indices were significantly higher in CH patients, correlating negatively with free thyroxine levels.
  • Systolic function remained normal, but diastolic dysfunction was evident.

Conclusions:

  • Neonates with CH may present with systolic and diastolic cardiac dysfunction.
  • Early L-T4 substitution therapy can reverse cardiac dysfunction in CH.
  • The Tei index is a valuable addition to conventional echocardiography for assessing CH cardiac function.
Abstract

Keywords:
Tei indexcongenitally hypothyroidismheart failuretissue Doppler echocardiography

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