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Related Experiment Videos

Gold - Old Drug with New Potentials.

Gavino Faa1, Clara Gerosa1, Daniela Fanni1

  • 1Dipartimento di Scienze Chirurgiche, Anatomia Patologica, University of Cagliari, Via Ospedale 46, I- 09124 Cagliari. Italy.

Current Medicinal Chemistry
|April 1, 2017
PubMed
Summary

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Correction: Ziranu et al. Navigating the Landscape of Liquid Biopsy in Colorectal Cancer: Current Insights and Future Directions. <i>Int. J. Mol. Sci.</i> 2025, <i>26</i>, 7619.

International journal of molecular sciences·2026

Gold compounds show promise in treating various diseases, including infections, arthritis, and cancer. Gold nanoparticles offer high efficacy and selectivity with low toxicity, expanding their use in modern medicine.

Area of Science:

  • Medicinal Chemistry
  • Nanomedicine
  • Pathology

Background:

  • Recent resurgence in research on gold-based drugs for diverse human diseases.
  • Gold(I) and Gold(III) compounds are being re-evaluated for clinical applications.
  • Targeting cellular mechanisms in viral, parasitic, autoimmune, and cancerous conditions.

Purpose of the Study:

  • To review the applications of gold compounds in various human pathologies.
  • To highlight the therapeutic potential of gold in infectious diseases, rheumatoid arthritis, and cancer.
  • To discuss the diagnostic and therapeutic roles of gold nanoparticles and colloidal gold.

Main Methods:

  • Review of existing literature on gold compounds in medicine.
  • Analysis of applications against Mycobacterium tuberculosis and in rheumatoid arthritis.
Keywords:
Goldcancercolloidal golddiagnosticsnanoparticlesrheumatoid arthritistoxic effectstuberculosis

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  • Examination of gold-based cancer therapies, including nanoparticle and photothermal approaches.

    • Main Results:

    • Gold compounds are effective against Mycobacterium tuberculosis and in rheumatoid arthritis treatment.
    • Gold nanoparticles and photothermal therapy show promise for cancer treatment.
    • Colloidal gold has diagnostic applications, and various gold derivatives are evaluated for safety and toxicity.

    Conclusions:

    • Gold exhibits a broad spectrum of therapeutic and diagnostic uses across degenerative, infectious, and cancerous diseases.
    • Gold nanoparticles are particularly promising due to high efficacy, cancer cell targeting, and low toxicity.
    • Gold-based therapies represent an evolving frontier in clinical medicine.