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Northern Shanghai Study: cardiovascular risk and its associated factors in the Chinese elderly-a study protocol of a
Hongwei Ji1, Jing Xiong1, Shikai Yu1
1Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Insights
This study aims to develop a cardiovascular disease (CVD) risk score for elderly Chinese individuals. The score will identify risk factors and target organ damage to guide future interventions for CVD prevention.
Area of Science:
- Cardiology
- Gerontology
- Epidemiology
Background:
- Cardiovascular diseases (CVD) are a leading global cause of death and disability.
- Aging populations worldwide are experiencing an increasing burden of CVD.
- China lacks robust cohort studies and established CVD risk scores for its elderly population.
Purpose of the Study:
- To establish a novel cardiovascular risk score tailored for community-dwelling elderly Chinese individuals.
- To identify key cardiovascular risk factors and assess target organ damage (TOD) in this demographic.
- To provide a basis for targeted interventions aimed at reducing CVD burden in older Chinese adults.
Main Methods:
- The Northern Shanghai Study is a prospective, community-based cohort study.
- Participants undergo baseline and biennial assessments, including clinical examinations, anthropometrics, questionnaires, and biochemical measurements.
- Comprehensive assessments include blood pressure, carotid ultrasonography, echocardiography, pulse wave analysis, and evaluation of TOD and conventional CVD risk factors.
Main Results:
- The study is ongoing, with pre-results available.
- The Northern Shanghai Risk Score will be calculated incorporating identified cardiovascular risk factors and TOD.
- Long-term follow-up will record the incidence of cardiovascular events and mortality.
Conclusions:
- The development of a specific CVD risk score for the elderly Chinese population is crucial.
- Understanding associated risk factors and TOD will inform personalized prevention strategies.
- This research aims to reduce the significant burden of cardiovascular disease in aging Chinese communities.
Introduction:
Cardiovascular (CV) diseases are the leading cause of death and disability in the world. Increasing lifespans and ageing populations also contribute to an increasing CV burden. However, in China, there were few well-designed cohort studies focusing on the elderly population, let alone an established CV risk score. The objective of this study is to establish a CV risk score based on a community-dwelling Chinese elderly population, determining the profile of the associated CV risk factors and target organ damages (TODs), so as to guide the later intervention.
Methods And Analysis:
The Northern Shanghai Study is an ongoing prospective community-based study. After enrolment, clinical examination, anthropometric measurement and a questionnaire will be administered to each participant at baseline and after every 2 years in the follow-up. Our tests and examinations include: blood/urine sample and biochemical measurements, office blood pressure recording, carotid ultrasonograph, echocardiograph, pulse wave velocity, pulse wave analysis, 4-limb blood pressure recording, body mass index, etc. Baseline measurement will also include the assessments on TODs and the conventional CV risk factors. In the follow-up, the incidence of CV events and mortality will be recorded. The Northern Shanghai Risk Score will be calculated, with considerations on CV risk factors and TODs.
Ethics And Dissemination:
This study was approved by the Shanghai Tenth People's Hospital Institutional Review Board. All participants signed a written consent form.
Trial Registration Number:
NCT02368938; Pre-results.