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Tumefactive Fibroinflammatory Lesion: A Diagnostic Dilemma
Promil Jain1, Rajeev Sen1, Nisha Sharma1
1Department of Pathology, Pt BDS PGIMS, University of Health Sciences, Rohtak, India.
Iranian Journal of Medical Sciences
|April 1, 2017
Summary
Tumefactive fibroinflammatory lesions (TFLs) are rare benign growths mimicking cancer. This case highlights a young female with a TFL presenting as rapid cheek swelling, emphasizing the need for long-term patient follow-up due to high recurrence rates.
Area of Science:
- Pathology
- Oncology
- Radiology
Background:
- Tumefactive fibroinflammatory lesions (TFLs) are rare, idiopathic, benign fibrosclerosing conditions.
- Clinically, TFLs can mimic malignancy, posing diagnostic challenges.
Observation:
- TFLs most commonly affect males aged 10-74, typically in the head and neck region.
- This report details a rare case of TFL in a young female presenting with rapidly progressing cheek swelling.
Findings:
- Histopathology confirms TFLs as benign, non-neoplastic, fibroinflammatory proliferations, despite their malignant clinical appearance.
- The etiology of TFLs remains largely unknown, with theories suggesting exaggerated immune responses or autoimmune reactions to chronic infections.
Implications:
- The variable and not well-defined treatment strategies for TFLs include steroids, surgery, and radiotherapy.
- Despite being non-fatal, TFLs exhibit high recurrence rates, necessitating prolonged patient monitoring and follow-up.